Oclacitinib mexico

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The road to itch relief felt like a long one, until APOQUEL


APOQUEL® (oclacitinib tablet) has been prescribed to more than 9 million dogs in need of fast and effective allergic itch relief.1,2


Apoquel (oclacitinib)Apoquel (oclacitinib)


Apoquel (oclacitinib)

Fast and effective

APOQUEL is the #1 prescribed medicine for allergic itch3

Effective for flea allergy, food allergy, contact allergy, atopic dermatitis4,5

Effective for fleas, food allergy, contact allergy and atopic dermatitis

APOQUEL delivered fast relief that began to control itch within 4 hours, comparable to oral steroids, in dogs with allergic dermatitis6,7

Apoquel delivered fast relief vs steroids

*The dose of prednisolone was lowered at Day 6 to account for the real-world dosing scenario of prednisolone.

Inclusion Criteria

Study design

APOQUEL exhibited faster onset of relief than Atopica® (cyclosporine capsules, USP) in the control of pruritus in dogs with atopic dermatitis8,9

Apoquel delivered fast relief vs Atopica

Atopica is a trademark of Elanco or its affiliates.

Inclusion Criteria

Study design

APOQUEL effectively controlled itch within 24 hours in dogs with allergic dermatitis4

Apoquel controls itch within 24 hours

Inclusion Criteria

Study design

Dogs with atopic dermatitis treated with APOQUEL experienced a significant and long-term reduction in itch10,11

Apoquel reduces itch in dogs

Inclusion Criteria

Study design

APOQUEL demonstrated a significant reduction in inflammation over the long term10,11

Apoquel reduces skin inflammation in dogs

Inclusion Criteria

Study design

In a study, APOQUEL was shown to be as effective as steroids in reducing skin inflammation at all time points6,7

Apoquel is as effective as steroids at all time points

Inclusion Criteria

Study design

Multiple studies have demonstrated the anti-inflammatory effects of APOQUEL through its fast and significant reduction of allergic and atopic dermatitis6,7,11,12

Real-world results13


Boston Terrier Mix,
age 5, 30 lb

Marley before and after Apoquel
Marley before and after Apoquel

Allows diagnostic testing

The first step in providing allergic itch relief during diagnostic testing14

APOQUEL lets you establish and maintain allergic itch relief while allowing you to achieve a diagnosis

  • Fast itch control improves quality of life14 while you conduct diagnostic trials
  • Short half-life lets you "turn-on" and "turn-off" itch control during flea control and food trials

Relieve allergic itch with APOQUEL during an 8-week15 food trial

APOQUEL is not a steroid

First medicine specifically designed to target canine allergic itch and inflammation16,17

Works differently from steroids and cyclosporine17-19

  • Nonsteroidal APOQUEL targets specific cytokines that cause itch and inflammation, relieving symptoms of allergic skin disease with minimal impact on the immune system

Dog in fieldDog in field

Cytokines involved in dog allergies

APOQUEL inhibits the function of a variety of pruritogenic and proinflammatory cytokines, including JAK1- and JAK3-dependent cytokines involved in dog allergies…

Minimal effect on JAK-2 cytokines

…while having only minimal effect on JAK2-dependent cytokines involved in hematopoiesis and innate immunity

Apoquel (oclacitinib)

Short-term steroid use can cause side effects

  • 55% of dog owners report side effects with steroids. The most common include20:
    - Excessive thirst and urination
    - Increased hunger and appetite

  • APOQUEL works differently than steroids.17,18 Side effects reported most often are vomiting and diarrhea4

  • Balancing the need for relief with the consideration of side effects can create an emotional roller coaster for pet owners

The safety profile of APOQUEL is supported by pharmacovigilance data over 5 years

The overall adverse reactions incidence rate during a 5-year review is rare (more than 1 but less than 10 animals reacting per 10,000 treatments administered)21,22*

  • The incidence rate of the most commonly reported individual adverse reactions (in decreasing order: vomiting, diarrhea, lethargy, anorexia and bloodwork changes) associated with the use of APOQUEL was very rare (less than 1 dog out of 10,000 treated)22
  • Results are consistent with pre-approval pivotal safety and efficacy studies. APOQUEL is performing as expected under field conditions21,22

Safe to use in dogs 12 months of age and older

Side effects were similar to placebo over short term

  • Most common side effects in a short-term clinical trial included vomiting and diarrhea and were self-limiting4

Can be used long term for maintenance therapy

Can be used concomitantly with many medications, including NSAIDs, anti-infectives, parasiticides, antifungals and allergen-specific immunotherapy23

  • The use of APOQUEL has not been evaluated in combination with other systemic immunosuppressants, such as corticosteroids and cyclosporine

Not for use in dogs with serious infections or for use in breeding, pregnant or lactating dogs

*Rare is defined as more than 1 but less than 10 animals reacting per 10,000 treatments administered; very rare is defined as less than 1 animal reacting per 10,000 treatments administered. Reported incidence rate (calculated) is an estimated rate. Includes all ARs regardless of whether the product was administered per label directions, concomitantly or if a potential causal relationship existed.22

APOQUEL vs placebo4

Apoquel vs placebo safety chart

Study design

APOQUEL vs prednisolone7

Apoquel vs prednisolone safety chart

Study design

APOQUEL vs placebo11

Apoquel vs placebo ae chart

Study design

APOQUEL vs Atopica® (cyclosporine capsules, USP)9

Apoquel vs atopica ae chart

Study design

How to dose APOQUEL

  • The dose of APOQUEL tablets is 0.18 to 0.27 mg/lb (0.4 to 0.6 mg/kg)
  • APOQUEL should be given twice daily (BID) for up to 14 days of therapy and once daily (SID) thereafter for maintenance
  • APOQUEL may be given with or without food
  • APOQUEL may be discontinued without tapering


Apoquel dose chart

APOQUEL is #1 in veterinarian and pet owner satisfaction24,25

Veterinarians feel confident when prescribing APOQUEL26

“APOQUEL is a reliable, fast-acting way to ensure the pet finds relief from itching.”

— Dr Holly Dutton,
North Bay Animal Hospital, FL

“APOQUEL works well to provide relief, increasing owners' confidence in our recommendation and building trust that we are going to help their pets.”

— Dr Samantha Lockwood,
Dermatology for Animals, AZ

“Whenever you solve a problem for a pet owner, it always results in increased trust and more acceptance of other recommendations.”

— Dr Farid Saleh,
Erlich Animal Hospital, FL

Pet owners are highly satisfied with APOQUEL treatment for their dogs27

90%would recommend APOQUEL to a friend

96%believed APOQUEL improved the quality of their dog’s life

94%said APOQUEL improved the quality of their own life

Hear what your peers have to say about APOQUEL!


Apoquel (oclacitinib)Apoquel (oclacitinib)


Apoquel (oclacitinib)

*Based on survey data from veterinarians (n=250) and pet owners (n=150).

APOQUEL is now a part of Zoetis Petcare Rewards

Clients can earn money for future veterinary visits with Zoetis Petcare Rewards. With every APOQUEL purchase, pet owners can earn rewards! Rewards can help pay for any product or service at your veterinary practice. Clients can spend their rewards on anything they choose at the veterinary office for their pet’s care.


APOQUEL dosing guide

Save the APOQUEL dosing table to use in your practice


APOQUEL technical monograph

A comprehensive overview of allergic skin disease and APOQUEL, including pharmacology and clinical trials


Steroid side effects one-pager

A simple diagram that reviews short- and long-term side effects of steroids


Client information sheet

Clinical information sheet

Gives dog owners a quick overview of allergic skin disease and a review of APOQUEL treatment, explaining what to expect


Itch tracker

Helps your clients track the improvement in their dog’s itch


Pet owner brochure

An informative review of APOQUEL for your customers; can be used in the waiting room or given to owners whose dogs have been prescribed APOQUEL


Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Do not use APOQUEL in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.
For more information, please see the full Prescribing Information.

References: 1. Data on file, 2014-2018 Apoquel Brand Health, 2019, Zoetis Inc. 2. Data on file, Unique Patient Count from Launch, 2020, Zoetis Inc. 3. Data on file, Monthly VetStreet Report, December 2018, Zoetis Inc. 4. Cosgrove SB, Wren JA, Cleaver DM, et al. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. Vet Dermatol. 2013;24(5):479-e114. doi:10.1111/vde.12047. 5. Moriello KA. Canine allergic dermatitis: pathogenesis, clinical signs, and diagnosis. DVM 360. May 31, 2006. Accessed June 29, 2020. https://www.dvm360.com/view/canine-allergic-dermatitis-pathogenesis-clinical-signs-and-diagnosis. 6. Gadeyne C, Little P, King VL, et al. Efficacy of oclacitinib (APOQUEL®) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Vet Dermatol. 2014;25(6):512-e86. doi:10.1111/vde.12166. 7. Data on file, Study Report No. A161R-AU-12-096, Zoetis Inc. 8. Little PR, King VL, Davis KR, et al. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Vet Dermatol. 2015;26(1):23-e8. doi:10.1111/vde.12186. 9. Data on file, Study Report No. 6962R-14-10-025, Zoetis Inc. 10. Data on file, Study Report No. 1962C-60-10-A16, Zoetis Inc. 11. Cosgrove SB, Wren JA, Cleaver DM, et al. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (APOQUEL®) in client-owned dogs with atopic dermatitis. Vet Dermatol. 2013;24(6):587-e142. doi:10.1111/vde.12088. 12. Data on file, Study Report No. 1962C-60-09-930, Zoetis Inc. 13. Data on file, Pet Owner Case Study–Marley, Zoetis Inc. 14. Aleo MM, Galvan EA, Fleck TJ, et al. Effects of oclacitinib and prednisolone on skin test sensitivity [abstract]. Vet Dermatol. 2013;24(3):297. 15. Olivry T, Mueller RS, Prélaud P, et al. Critically appraised topic on adverse food reactions of companion animals (1): duration of elimination diets. BMC Vet Res. 2015;11:225. doi:10.1186/s12917-015-0541-3. 16. Data on file, Press Release, 2014, Zoetis Inc. 17. Gonzales AJ, Bowman JW, Fici G, et al. Oclacitinib (APOQUEL®) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. J Vet Pharmacol Ther. 2014;37(4):317-324. doi:10.1111/jvp.12101. 18. Coutinho AE, Chapman KE. The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 2011;335(1):2-13. doi:10.1016/j.mce.2010.04.005. 19. Guaguère E, Steffan J, Olivry T. Cyclosporin A: a new drug in the field of canine dermatology. Vet Dermatol. 2004;15(2):61-74. doi:10.1111/j.1365-3164.2004.00376.x. 20. Data on file, Pet Owner Quantitative Market Research, 2013, Zoetis Inc. 21. Data on file, A Five-Year Post-Approval Safety Review for APOQUEL® in the US (May 2013 to August 2018), Zoetis Inc. 22. Volume 6C Summary of the Product Characteristics: SPC European Commission, Brussels. 1 Vol. 6C. July 10, 2006, 1-11. 23. Cosgrove SB, Cleaver DM, King VL, et al. Long-term compassionate use of oclacitinib in dogs with atopic and allergic skin disease: safety, efficacy and quality of life. Vet Dermatol. 2015;26(3):171-179. doi:10.1111/vde.12194. 24. Data on file, APOQUEL/CYTOPOINT Vet Tracker Wave 11, 2018, Zoetis Inc.25. Data on file, APOQUEL/CYTOPOINT Pet Tracker Wave 6, 2019, Zoetis Inc. 26. Data on file, APOQUEL Customer Survey, 2019, Zoetis Inc. 27. Data on file, APOQUEL Early Experience Program Pet Owner Aggregate Data, 2014, Zoetis Inc. 28. Data on file, Pet Owner Case Studies–Bijou, Nani, Gunner, Captain and Molly, Zoetis Inc.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted.
© 2021 Zoetis Services LLC. All rights reserved. APQ-00371R4

Sours: https://www.zoetisus.com/products/dogs/apoquel/index.aspx
  • La dosis de Apoquel® (Oclacitinib) es de: 0.4 a 0.6 mg/kg.
  • Apoquel® debe ser administrado cada 12 horas (dos veces al día) por 14 días y a partir del día 15 una vez al día para mantenimiento.
rango de peso en kgnúmero de tabletas que se deben administrar
3.6 mg
5.4 mg
16 mg


















  • Asegúrese que la dosificación se proporcione como se indica: los primeros 14 días cada 12 horas y el cambio a una sola toma a partir del día 15.
  • Haga énfasis con el dueño de la mascota para que verifique que el perro ingiera la tableta.
  • Utilice un registro para evaluar la intensidad del prurito.
  • Procure hacer un registro fotográfico de los cambios en la piel del perro, conforme avanza el tratamiento.
  • Agende una segunda revisión a los 5 o 7 días, esto le permitirá verificar el avance y eficacia de los tratamientos establecidos, detectar errores o falta de efectividad y realizar algún ajuste si es necesario.
  • El tener un seguimiento puntual le ayudará a generar confianza por parte del dueño de la mascota.
Sours: https://www.apoquel.mx/vet/doses.aspx
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Is there a generic available for Apoquel (oclacitinib)? How can dog owners save money on Apoquel?

Apoquel (oclacitinib) is prescribed for the treatment and control of itching (canine pruritus) and inflammation in dogs that can come about for a number of reasons. Just like us, your dog may at some point develop certain allergies. Your pet may exhibit irritation from a flea, food, or contact allergy; or atopic dermatitis. Studies show that up to 10% of pups are affected by atopic dermatitis. Apoquel works by blocking the activity of certain proteins that cause your pet to be so uncomfortable.

Compare Apoquel Prices

Luckily, according to Dr. Melissa Eisenschenk, DVM, DACVD, “Apoquel works rapidly, (and) most pets see complete relief within two days.”

Compare Apoquel Prices

Back in May 2013, the FDA approved Apoquel, “for the control of pruritus associated with allergic dermatitis and the control of atopic dermatitis in dogs at least 12 months of age.” The generic name for Apoquel is its active ingredient, oclacitinib. As of October 2019, a generic version has still not been approved in the U.S. and is not available from accredited online pharmacies located abroad. So, if you were counting on a generic counterpart to ease financial burdens, you’re out of luck. No need to fret, though! There are opportunities right here in the U.S. to curb your vet clinic medication spending.

How to Cut Costs on Apoquel (oclacitinib)

Federal (USA) law restricts this drug only for use by or on the order of a licensed veterinarian; therefore, dog owners cannot get Apoquel at their local Costco or Walmart with a coupon, rather at the office of their vet. It may surprise pet owners and vets to read this, but Apoquel may be purchased at a lower cost in the U.S. than from Canada or other countries.

Pet owners can earn money to use for future vet visits every time they purchase Apoquel.

Learn more about Zoetis Petcare Rewards

So what is the cheapest way to get Apoquel? The lowest price for 100 tablets of Apoquel 16mg at accredited international online pharmacies is $228.99. This particular pharmacy would ship the medication from the United Kingdom at no additional cost. Veterinarians can get the same amount for $219 from 1-800-PetMeds in the U.S. Although the savings isn’t substantial, it can really add up when you’re running a busy clinic. Be sure to compare costs before you buy though! Apparently, the strength is a factor for savings. Apoquel is cheaper at international online pharmacies in the case of Apoquel, strengths 3.6mg and 5.4mg. See the chart below.

Compare Apoquel Prices

Cost Comparison of Dog Allergy Medication Apoquel

Drug Name Strength (Quantity) U.S. Discount Coupon Price (1-800-PetMeds) Lowest International Pharmacy Price (shipping included)
Apoquel 3.6mg (100 tablets)   $179$167.99
Apoquel 5.4mg (100 tablets)   $199$171.99
Apoquel 16mg (100 tablets)   $219.00$228.99

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Can pet owners get Apoquel without a prescription?

Apoquel is not available over the counter. You cannot buy Apoquel without presenting a valid prescription from your vet.

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Apoquel Dosing Guide For Dogs

Your Dog’s Weight

Number of Tablets to be Administered per Dose


3.6 mg tablets

5.4 mg tablets

16 mg tablets

6.6 – 9.9 lbs 0.5 - -
10 – 14.9 lbs - 0.5 -
15 – 19.9 lbs 1 - -
20 – 29.9 lbs - 1 -
30 – 44.9 lbs - - 0.5
45 – 53.9 lbs 0.5   0.5
54 – 59.9 lbs - 0.5 0.5
60 – 89.9 lbs - - 1
90 – 129.9 lbs - - 1.5
130 – 175.9 lbs - - 2

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Where is Apoquel (oclacitinib) made?

Apoquel sold in the U.S. is manufactured in Italy and distributed by Zoetis Inc. (see packaging below).

Apoquel manufacturing

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Dog Allergy Medication Alternatives to Apoquel (oclacitinib)

Although Apoquel is a commonly prescribed drug for the treatment of allergies in dogs, it’s certainly not a pet owner’s only option to help out their furry friend.

Although drugs like Zyrtec and hydroxyzine are not FDA-approved for animals, some vets are prescribing the drug “off-label.”

Also, talk to your vet about topical solutions for itching. Regular baths, flea medication, the right diet for your dog, allergy elimination therapy, and probiotics can also be considered under the guidance of your veterinarian.




Compare Apoquel Prices Today

Compare prices among U.S. discount coupons and accredited international online pharmacies

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Compare drug prices among reputable online pharmacies

Sours: https://www.pharmacychecker.com/askpc/apoquel-vets-pet-meds-generic/
Dog from APOQUL TV commercial lying down

Enter the My APOQUEL Story Sweepstakes for a chance to win $250 in rewards!

Has your dog found relief from allergic itch with APOQUEL®?
We would love to hear about your dog’s journey and how life has changed since starting APOQUEL. When you share your APOQUEL Story, along with a photo or video of your dog, you’ll be automatically entered for a chance to win $250 in rewards (2,500 points) to spend at a veterinarian with Zoetis Petcare Rewards! Plus, your story may be featured on our website in the future.



Please see Sweepstakes Terms and Conditions

Dog from APOQUL TV commercial lying down

Important Safety Information: Do not use APOQUEL in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. APOQUEL has been used safely with many common medications including parasiticides, antibiotics and vaccines.

For more information, please see the full Prescribing Information.


Control of pruritus (itching) associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.

Sours: https://www.apoqueldogs.com/share-your-story.aspx

Mexico oclacitinib

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