Omeprazole withdrawal side effects

Omeprazole withdrawal side effects DEFAULT

Omeprazole Withdrawal Symptoms (What You Might Experience)

Omeprazole, manufactured the trade names Prilosec and Losec, is a proton-pump inhibitor prescribed for the management of medical conditions such as: gastroesophageal reflux disease (GERD); peptic ulcer disease; Zollinger-Ellison syndrome; and forms of esophagitis (erosive and eosinophilic).  In some cases, omeprazole is also utilized as a prophylactic to prevent upper gastrointestinal bleeding in at-risk populations.

As a selective and irreversible proton-pump inhibitor (PPI), omeprazole functions by inhibiting the enzyme H+/K+-ATPase (hydrogen/potassium-ATPase) to suppress the production of stomach acid.  Although many people derive substantial therapeutic benefit from omeprazole’s action as a proton-pump inhibitor, some users might: find the medication ineffective and/or difficult to tolerate (due to omeprazole side effects) – or use it for a while and eventually desire to try functioning without it.

Among persons who don’t respond well to omeprazole, dislike its side effects, and/or want to try functioning without it – omeprazole discontinuation may be warranted.  Though most individuals will have no major issues with the discontinuation process, others may experience unexpected and/or debilitating omeprazole withdrawal symptoms.

Omeprazole Withdrawal Symptoms (List of Possibilities)

Included below is a list of withdrawal symptoms that have been documented by former omeprazole users following discontinuation.  Prior to reading through the list of symptoms, it is important to underscore the fact that the specific withdrawal symptoms (and the severities of those symptoms) occurring after omeprazole cessation will be subject to interindividual variation.

In other words, the specific withdrawal symptoms that you experience after quitting omeprazole might differ significantly from those reported by other former users.  However, data from scientific studies (in which proton-pump inhibitor withdrawal symptoms were reported) indicate that several discontinuation symptoms are more common than others, including:  heartburn (~45%), dyspepsia (~30%), acid regurgitation (~25%).

  1. Heartburn (45%)

According to data from a study by Reimer et al. (2009), heartburn is one of the most common symptoms that emerges following of proton-pump inhibitor discontinuation.  For reference, heartburn is a specific form of indigestion commonly described as a “burning sensation” in the center of the chest (or near the heart).

The specific cause of heartburn in omeprazole withdrawal is probably hypersecretion of stomach acid which causes acid regurgitation into the esophagus, and as a result, a “burning sensation” within the upper chest.  Taking into consideration data from the aforementioned study by Reimer et al., it’s reasonable to estimate that heartburn might occur in around 45% of former omeprazole users during the first 4 weeks after discontinuation.

In the study by Reimer et al., the severity of heartburn following proton-pump inhibitor discontinuation was reported as being “mild-to-moderate.”  That said, because the Reimer et al. study involved healthy individuals, it’s fair to hypothesize that heartburn might be more severe in withdrawal among persons with preexisting gastroesophageal conditions.

  1. Indigestion or Dyspepsia (30%)

Data from a study by Reimer et al. (2009) indicate that indigestion (medically referred to as “dyspepsia”) is the second most frequently-reported symptom that emerges following discontinuation of proton-pump inhibitors.  Reflecting upon available data from the aforementioned Reimer et al. study, indigestion was reported to have occurred in approximately 30% of former proton-pump inhibitor users within 4 weeks of cessation.

The cause of indigestion (impaired or irregular digestion) during withdrawal is understood to be rebound stomach acid hypersecretion – or excessive production of stomach acid following proton-pump inhibitor cessation.  The severity of indigestion reported in the Reimer et al. study was documented as being “mild-to-moderate” based on self-reports.

Nevertheless, because the Reimer et al. study involved healthy participants, it’s fair to speculate that indigestion may be of heightened severity among patients with preexisting gastroesophageal irregularities – throughout withdrawal.  Moreover, if indigestion occurs in withdrawal, it might trigger or exacerbate concurrent reactions such as: appetite reduction, belching, heartburn, nausea, stomach fullness, and/or stomach pain.

  1. Acid regurgitation (25%)

Acid regurgitation (colloquially referred to as “acid reflux”) was reported by in a study by Reimer et al. (2009) as being the third-most common symptom of proton-pump inhibitor withdrawal.  The cause of acid regurgitation in withdrawal is likely rebound stomach acid hypersecretion whereby stomach acid flows back up into the esophagus.

In the aforementioned study by Reimer et al., approximately 25% of healthy individuals experienced significant acid regurgitation (of mild-to-moderate severity) after discontinuing proton-pump inhibitors following an 8-week treatment phase.  Because the study by Reimer et al. involved healthy individuals, many speculate that the prevalence and severity of acid regurgitation in withdrawal may be greater in populations with preexisting gastroesophageal conditions.

Other symptoms of omeprazole withdrawal

In addition to the 3 most scientifically-substantiated omeprazole withdrawal symptoms (heartburn, indigestion, and acid regurgitation) – other symptoms have been reported by former users.  Though it’s unclear as to whether these additional symptoms are legitimately attributable to omeprazole withdrawal, it’s not unreasonable to consider the possibility.

Rebound acid hypersecretion that occurs during omeprazole withdrawal could provoke symptoms like: bloating, gas, nausea, stomach aches, and weight change.  Moreover, rebound acid hypersecretion might alter gut bacteria, increase inflammation (e.g. cytokine levels), and increase oxidative stress to trigger neuropsychiatric symptoms such as: anxiety, depression, headache, insomnia, etc.

  • Anxiety: Even if you don’t have a history of anxiety, it’s possible that anxiety, nervousness, or panic attacks could emerge as omeprazole withdrawal symptoms due to changes in gut bacteria, heightened production of inflammatory cytokines, and/or increased oxidative stress – all stemming from rebound acid hypersecretion.  Persons with anxiety disorders and/or neuropsychiatric conditions may be most “at risk” for experiencing anxiety during withdrawal due to preexisting neurochemical abnormalities.
  • Appetite loss: Many individuals have reported appetite reduction and/or appetite loss after quitting omeprazole.  Appetite loss could occur for a variety of reasons in withdrawal, but is most likely attributable to rebound acid hypersecretion.  Rebound acid hypersecretion in withdrawal can induce symptoms such as: bloating, heartburn, indigestion, nausea, and stomach pain – each of which might suppress appetite.  Appetite loss in withdrawal might also be triggered and/or exacerbated by anxiety and/or depression.
  • Bloating: Increased gastric acid production following omeprazole discontinuation can lead some individuals to experience bloating. The bloating may cause and/or be accompanied by: appetite loss, stomach pain, indigestion, and/or weight gain (due to increased water retention).  Until rebound acid hypersecretion in withdrawal subsides, bloating may persist.  Staying properly hydrated and avoiding excessive dietary sodium may help counteract the bloat.
  • Constipation: Some individuals may experience constipation after discontinuing omeprazole. The constipation experienced in withdrawal may be due to decreased gastric motility or a prolongation in the movement of food through the gastrointestinal tract – probably due to fluctuations in the production of stomach acid.  If you’re constipated in withdrawal, consider: evaluating your hydration, engaging in more physical activity, and/or tweaking your diet.
  • Depression: Though depression is not considered a common omeprazole discontinuation symptom, a small percentage of former users have reported mild depression after stopping treatment.  It is believed that individuals with preexisting neuropsychiatric disorders are at greatest risk for experiencing depression in withdrawal.  Possible causes of transient depression in withdrawal could include: increased inflammation; gut bacteria changes; and/or oxidative stress.
  • Diarrhea: Although some individuals may experience constipation during omeprazole withdrawal, others might end up with diarrhea. Diarrhea in withdrawal might be provoked by excessive production of stomach acid such that the gastrointestinal tract becomes irritated and/or inflamed – and ingested foods move rapidly through the gastrointestinal tract.  If you have frequent bowel movements following omeprazole cessation – ask your doctor whether it would be a good idea to use antidiarrheal agents.
  • Dizziness & lightheadedness: Many former omeprazole users report dizziness and lightheadedness after stopping the medication. The dizziness and lightheadedness that emerge in withdrawal could have a myriad of potential causes, including: vitamin/mineral deficiencies, electrolyte imbalances, blood pressure changes, and/or increased inflammation.  In most cases, dizziness and lightheadedness will resolve within a week or two of omeprazole cessation.
  • Fatigue: Dealing with omeprazole discontinuation symptoms can sometimes drain your energy (physical and mental). At times, you may experience tiredness, drowsiness, or fatigue – as your body attempts to normalize its gastric acid production without the influence of omeprazole.  Like other discontinuation symptoms, fatigue should decrease significantly within a couple of weeks following complete cessation.  That said, poor sleep and/or unmanaged inflammation will exacerbate the fatigue.
  • Flu-like symptoms: After discontinuing omeprazole, you may experience a combination of flu-like symptoms such as: nausea, stomach aches, headache, and dizziness. These flu-like symptoms are usually most severe and/or noticeable within the first week of discontinuation.  Staying adequately hydrated, supplementing with electrolytes and vitamins, and using anti-inflammatories may help you manage the flu-like feeling.
  • Gas (Flatulence): Even though flatulence (or gas accumulation) is a side effect of omeprazole, it is also a discontinuation symptom that a subset of former users will experience in withdrawal. Changes in stomach acid production following omeprazole cessation can lead to a combination of indigestion, bloating, constipation, and flatulence.  The gas buildup may be accompanied by gurgling or rumbling sounds in your stomach – and may feel slightly uncomfortable or painful.
  • Headache: After completely discontinuing omeprazole, certain individuals may experience frequent and/or severe headaches. Although headaches aren’t necessarily a common withdrawal symptom, headaches could be provoked by: increased inflammation; dietary changes; electrolyte imbalances; dehydration; suboptimal sleep; and/or heightened anxiety/stress.  To manage withdrawal-related headaches, be sure that you’re staying hydrated, eating a nutrient-dense diet, and minimizing stress.
  • Insomnia & poor sleep: Due to a resurgence of gastric acid production after stopping omeprazole, some individuals might experience insomnia and/or poor sleep. Specifically, elevated gastric acid secretion in withdrawal could cause acid reflux, heartburn, and indigestion – each of which could interfere with one’s ability to fall asleep and/or stay asleep.  Heightened anxiety, mood changes, constipation, inflammation, changes in diet, etc. – might also trigger insomnia and/or sleep disturbances.
  • Muscle tension: Heightened muscle tension, joint pain, and/or soreness have been reported as omeprazole discontinuation symptoms by a subset of former users. Increased muscle tension and/or joint pain after stopping omeprazole might be attributable to increased peripheral inflammation and/or altered production of peripheral neurotransmitters.
  • Nausea & vomiting: Nausea is a common symptom of omeprazole withdrawal that can be caused by rebound acid hypersecretion. In other words, because stomach enzymes are producing more acid than they did while using the medication, this sudden increase in acidification induces acid reflux, indigestion, and predictably – nausea.  Although nausea in withdrawal is generally manageable, in severe cases it might lead to vomiting.
  • Shakiness or trembling: According to anecdotal reports published online, one of the most common symptoms of omeprazole discontinuation is shakiness or trembling. Many report that their body constantly shakes or trembles uncontrollably for the first week or two after omeprazole cessation.  If you’re experiencing extreme shakes, this could be a sign that you need to taper off of omeprazole at a slower rate.
  • Stomach aches: If the medical condition for which omeprazole was originally prescribed resurfaces in withdrawal and/or you experience a transient spike in gastric acid production – this could certainly cause stomach aches. The stomach aches or pains that have been reported in omeprazole withdrawal could be relatively severe.  Although dietary modifications and supplements might help, anyone experiencing debilitating stomach pain after stopping omeprazole should seek medical attention.
  • Weight change: Body weight fluctuations can occur after stopping omeprazole for a variety of reasons. If you experience any significant increase or decrease in appetite during withdrawal, this will likely influence how much food you consume – and could explain your weight change.  Other withdrawal symptoms like bloating and constipation might induce a transient, modest weight increase – whereas withdrawal symptoms like diarrhea might yield transient weight loss.

Note: The above list of withdrawal symptoms associated with omeprazole might be incomplete.  If you happen to know of additional symptoms that might occur following omeprazole discontinuation, report them in the comments section below.

Contrasting: Omeprazole withdrawal symptoms vs. Medical condition

It is important to emphasize that it’s often difficult to distinguish between omeprazole withdrawal symptoms and a relapse of the medical condition(s) for which omeprazole was prescribed to treat.  For example, in someone with gastroesophageal reflux disease (GERD), discontinuation of omeprazole will likely result in the resurfacing of unmanaged GERD symptoms.

In this hypothetical example, the individual with GERD may experience withdrawal symptoms due to omeprazole discontinuation, however, it may be impossible to differentiate withdrawal symptoms from a resurgence of GERD symptoms.  This is because omeprazole discontinuation is hypothesized to provoke “rebound acid hypersecretion” (RAH).

In other words, a greater amount of stomach acid might be produced in omeprazole withdrawal than was produced pre-treatment – even among persons with GERD.  As a result, the GERD symptoms may become more severe than ever (in some persons) – due to an overlap of: untreated GERD and withdrawal-induced rebound acid hypersecretion.

Though withdrawal symptoms may vary, it’s relatively logical to suggest the following: (1) any new symptoms reported following omeprazole cessation (i.e. symptoms never experienced before medication cessation) – are probably due to withdrawal; and (2) any symptoms that become significantly more severe than ever before (after omeprazole discontinuation) – are probably due to withdrawal.

How do we know that withdrawal symptoms occur from proton-pump inhibitors?  Well, there’s evidence from a trial in which 120 healthy adults were randomized to receive a proton-pump inhibitor (PPI) or a placebo for 8 weeks – followed by a 4 week monitoring phase thereafter.

A significant number of the proton-pump inhibitor recipients reported symptoms such as acid regurgitation, dyspepsia, and heartburn – in the 4 weeks following PPI treatment, whereas these reactions were not reported in the placebo users.  This supports the idea that withdrawal symptoms likely occur after omeprazole (and related medications) are discontinued.

What causes omeprazole withdrawal symptoms?

Because omeprazole withdrawal hasn’t been extensively researched or discussed in scientific literature, a subset of medical professionals may not buy into the concept of a withdrawal syndrome following the discontinuation of a proton-pump inhibitor.  Instead, it may be suggested that all symptoms arising following omeprazole discontinuation are merely due to a resurgence of the medical condition for which omeprazole was prescribed.

Nevertheless, there are data highlighting the emergence of clinically significant “rebound effects” or symptoms following cessation of proton-pump therapy, even in healthy volunteers.  Furthermore, there are numerous anecdotal reports on the internet documenting moderate-to-severe withdrawal symptoms following omeprazole cessation.

The underlying cause of omeprazole withdrawal symptoms is probably post-treatment physiological readjustment.  When a proton-pump inhibitor is administered regularly over a long-term (e.g. weeks, months, years) – it’s likely that the body adapts to its ongoing administration and presence such that enzyme expression, signaling cascades, etc. might shift slightly from homeostasis.

In fact, research by Qvigstad et al. (1998) suggests that proton-pump inhibitors might induce similar physiologic adaptations as histamine (H2) receptor antagonists (another class of drugs prescribed to reduce gastric acid production).  Although there’s no evidence to substantiate the idea of “tolerance” to omeprazole, it’s likely that ongoing treatment could induce subtle physiologic adaptations.

Perhaps when omeprazole is discontinued, the former user’s physiology remains in an omeprazole-adapted state such that, for a week or two following discontinuation, gastric acid production is greater than usual (homeostatic baseline) – possibly due to the fact that the body upregulated its endogenous production of gastric acid to counterbalance the acid-lowering effect of omeprazole.  Thus, when the medication is discontinued, the increased gastric acid production might [transiently] linger and cause unwanted “withdrawal symptoms.”

What about the neuropsychiatric manifestations of withdrawal?  For those reporting neuropsychiatric symptoms after discontinuing omeprazole, it’s possible that transient rebound acid hypersecretion might alter gut bacteria and cause inflammation.  Altered gut bacteria and/or proinflammatory cytokines in the peripheral could undergo central uptake to alter neurotransmitter concentrations and provoke anxiety, depression, headaches, etc.

Variables that influence the severity of omeprazole withdrawal

Included below is a list of variables that might influence the severity of omeprazole withdrawal symptoms.  Variables that could influence withdrawal symptom severity include: duration of omeprazole treatment; omeprazole dosage; and rate of discontinuation.  A person’s lifestyle (diet, exercise habits, stress) and/or genetics might also impact withdrawal severity.

  1. Duration of omeprazole treatment

The total amount of time over which you’ve been using omeprazole might influence the difficulty of your withdrawal.  Most research and anecdotal reports suggest that extremely brief or short-term omeprazole treatment (e.g. several days) is unlikely to cause discontinuation symptoms.

If withdrawal symptoms occur following short-term omeprazole use, they are unlikely to be severe and/or protracted.  Comparatively, it is thought that moderate-term (weeks/months) and long-term omeprazole administration increase one’s risk of rebound acid hypersecretion – and severe withdrawal symptoms.

According to survey data moderate-term proton-pump inhibitor use induces withdrawal symptoms of mild-to-moderate severity (in a subset of former users).  Nevertheless, because omeprazole and proton-pump inhibitors don’t appear to induce clinically significant tolerance (even with long-term use), there may not be noticeable differences in withdrawal severity between moderate-term and long-term users.

  1. Omeprazole dosage (during treatment)

The dosage of omeprazole utilized during treatment might also influence the severity of discontinuation symptoms.  Specifically, it is thought that high-dose omeprazole users might be at greater risk of experiencing severe withdrawals in comparison to persons who used omeprazole at low doses.

Firstly, it is necessary to underscore the fact that individuals who used omeprazole at high doses probably had more substantial acid reflux at baseline (before treatment) – than persons who used lower-dose omeprazole.  This considered, it’s reasonable to speculate that, when a high-dose user discontinues treatment – severe acid reflux may resurface, whereas when a low-dose user discontinues treatment – more manageable acid reflux may resurface.

The resurgence of a severe acid reflux condition might exacerbate withdrawal symptoms for the former high-dose user – whereas symptom exacerbation might be less significant for the low-dose user.  Moreover, if physiologic adaptations are incurred from omeprazole administration – then the adaptations might be more significant among high-dose users.

If more significant physiologic adaptations are incurred by high-dose users (than low-dose users), then there might be a more significant rebound effect (e.g. rebound acid hypersecretion) after discontinuation.  For this reason, one might expect withdrawal symptoms to be more severe among high-dose users – relative to low-dose users.

  1. Rate of omeprazole discontinuation

According to Haastrup et al. (2014), tapering appears to be the most effective strategy for abrupt discontinuation of proton-pump inhibitors like omeprazole, whereas abrupt or “cold turkey” discontinuation is more challenging.  It is thought that quitting cold turkey may increase likelihood of and/or severity of hypergastrinemia and rebound acid hypersecretion in withdrawal – especially among long-term users.

Most speculate that gradually tapering off of omeprazole guides the user’s physiology closer to homeostasis before complete cessation – allowing for quicker recovery and fewer discontinuation symptoms.  Conversely, it is thought that sudden discontinuation of omeprazole after long-term and/or high-dose use leaves the physiology in an omeprazole-adapted state (further from homeostasis) whereby withdrawal symptoms are more severe and longer-lasting.

Although some evidence presented by Reimer et al. (2009) suggests that there may be no difference in withdrawal symptom severity among those who discontinue proton-pump inhibitors abruptly versus those who taper, anecdotal accounts have reported fewer discontinuation symptoms after a gradual taper.  While the rate of omeprazole discontinuation may not influence the severity of everyone’s withdrawal symptoms – it might be a significant influencer of withdrawal severity for a subset of former users.

  1. Use of substances while withdrawing from omeprazole

If you’re using substances (e.g. medications, supplements, etc.) while withdrawing from omeprazole, you may be at lower risk of experiencing severe withdrawal symptoms than if you weren’t using any substances.  Obviously if you discontinue omeprazole and immediately transition to a different proton-pump inhibitor OR an acid reducing agent (e.g. an H2 antagonist) – you probably won’t notice any withdrawal symptoms because these substances will exert similar effects as omeprazole.

Moreover, even if you’re using substances that are unrelated to omeprazole (and that have no substantial effect on stomach acid production) such as: probiotics, anxiolytics, anti-inflammatories, etc. – it’s possible that using these substances might still attenuate the severity of discontinuation symptoms.  For example, if you’re using a probiotic, you might not experience as much stomach pain as you otherwise would’ve.

In summary, it is thought that individuals who transition from using omeprazole to nothing (zero substance use) are at greatest risk of experiencing severe withdrawal symptoms – compared to those who use substances to help mitigate withdrawals.  If you don’t notice any discontinuation symptoms, this could be due to your daily medication and/or supplement regimen.

  1. Former omeprazole user’s lifestyle

The lifestyle of a former omeprazole user might also influence how severe his/her withdrawal symptoms end up.  Individuals who regularly: consume a nutritious hypocaloric diet (with foods that don’t increase stomach acid production); exercise regularly; manage stress; and get adequate sleep – will probably: (1) have an easier time managing discontinuation symptoms; (2) experience fewer discontinuation symptoms; and (3) have an easier time dealing with a return of the medical condition for which omeprazole was prescribed – relative to persons who engage in unhealthy habits.

On the other hand, persons who: never exercise; consume an unhealthy, hypercaloric diet (with foods that increase stomach acid production); fail to manage stress; and don’t get proper sleep – will probably: (1) have a difficult time with omeprazole discontinuation; and (2) struggle to cope with a return of the medical condition for which omeprazole was prescribed.  Though lifestyle won’t always influence withdrawal severity – in many cases lifestyle will probably: attenuate OR exacerbate symptoms.

  1. Former omeprazole user’s gene expression

It is unclear as to why some individuals experience noticeable and/or severe omeprazole withdrawal symptoms – yet others experience zero significant discontinuation symptoms.  Although not substantiated with scientific research, it’s fair to speculate that differences in gene expression might determine which former omeprazole users experience withdrawal symptoms after discontinuation – and which don’t.

Perhaps expressing (or lacking) certain genes induces withdrawal symptoms like rebound acid hypersecretion after omeprazole discontinuation – and expressing (or lacking) other genes protects against discontinuation symptoms.  Moreover, subtle differences in gene expression might also account for differences in the specific discontinuation symptoms experienced (and/or the severities of those symptoms) – among those who report noticeable withdrawals.

How long does Omeprazole withdrawal last?

It is important to underscore the fact that not everyone who discontinues omeprazole will experience withdrawal symptoms.  Some individuals stop taking omeprazole and merely notice a return of excessive gastric acid production associated with the medical condition for which omeprazole was prescribed to treat.

Among those who experience withdrawal symptoms after discontinuing omeprazole, the duration of withdrawal will be subject to significant individual variation – likely based on aforementioned variables such as: treatment duration; dosage; rate of discontinuation; use of substances in withdrawal; lifestyle; and gene expression.  For this reason, some will report withdrawal symptoms lasting a few days – whereas others might report withdrawal symptoms lasting a few weeks.

Nevertheless, anyone discontinuing omeprazole should know that its acid suppressing effects may persist for 3 to 5 days after the final dose.  This means that for the first 5 days after discontinuation, you might be experiencing a combination of: (1) medication side effects; (2) a return of symptoms associated with the medical condition for which omeprazole was prescribed; and (3) withdrawal symptom onset.

Although no timeline is documented in the medical literature regarding how long omeprazole withdrawal will last – there are studies that have documented how long rebound acid hypersecretion persists after quitting proton-pump inhibitors.  Assuming withdrawal symptoms are caused by rebound acid hypersecretion, it’s likely helpful to know how long rebound acid hypersecretion might persist after discontinuation of a proton-pump inhibitor.

According to Teixeira (2011), rebound acid hypersecretion after a moderate duration of proton-pump inhibitor treatment usually begins in the second week following discontinuation – and can persist for 2 to 3 months until ECL cells (i.e. Enterochromaffin-like cells) normalize.  That said, if omeprazole withdrawal symptoms occur, symptoms might emerge by the fifth day of discontinuation – and remain noticeable for an average of 10 days.

Understand that most former omeprazole users will notice a reduction in withdrawal symptoms once they’ve been off of the medication for at least 2 weeks.  Additionally, most former users are likely to be fully recovered within 3 months of omeprazole cessation.  If symptoms persist for longer than 3 months after quitting omeprazole – these might be symptoms of a preexisting medical condition (rather than withdrawal symptoms).

How to minimize the severity of Omeprazole withdrawal symptoms

Though many people have successfully discontinued omeprazole without any withdrawal symptoms, others might: (1) be concerned about prospective withdrawal symptoms OR (2) be experiencing withdrawal symptoms after omeprazole cessation.  To minimize the severity of omeprazole withdrawal symptoms – consider following the recommendations below.

  1. Work with a medical doctor: For your personal safety, it is never recommended to quit omeprazole without first consulting a medical doctor. A medical doctor will be able to help you develop a tapering protocol – and/or recommend omeprazole alternatives (if necessary).  Moreover, a medical doctor will be able to recommend safe supplements and/or lifestyle changes that you can make to minimize the likelihood of a difficult withdrawal.
  2. Omeprazole transition: To completely avoid withdrawal symptoms following omeprazole cessation, a medical doctor may recommend transitioning to a different proton-pump inhibitor OR acid-reducing agent. Assuming you have a chronic medical condition for which treatment with an acid-reducing agent is necessary – you probably won’t want to quit omeprazole without having an alternative medication – as symptoms of your condition will return.
  3. Omeprazole taper: If you plan on quitting omeprazole and all acid-reducing agents, then it may be better to conduct a slow taper (dosage reduction) rather than quitting cold turkey. According to Haastrup et al. (2014), tapering is a more effective method of PPI discontinuation than cold turkey cessation.  Researchers Pasina et al. (2016) recommend halving the dose for 4 to 8 weeks before stopping.  Other online sources recommend tapering at a rate of 25% per week (or reducing the dose by 25% each week until down to nothing).
  4. Use medications & supplements: While discontinuing omeprazole, it is recommended to use all medications and/or supplements that are recommended by a medical doctor. Using prescription medications, over-the-counter medications, and/or dietary supplements may help prevent rebound acid hypersecretion and/or debilitating discontinuation symptoms.
  5. Live a healthy lifestyle: Living a healthy lifestyle such as by eating a nutritious diet, exercising regularly, minimizing stress, and getting adequate sleep – should make it easier to cope with withdrawal symptoms. Furthermore, living a healthy lifestyle might decrease the severity of withdrawal symptoms that you experience – and a resurgence of the medical condition for which omeprazole was prescribed to treat.

Best supplements for Omeprazole withdrawal symptoms

Included below is a list of supplements and/or products that may be helpful to use while withdrawing from omeprazole.  Some of these supplements may help prevent and/or counteract rebound acid hypersecretion or attenuate the severities of various omeprazole discontinuation symptoms.

It is important to emphasize that not everyone will find these supplements to be useful after quitting omeprazole – or other proton-pump inhibitors.  Moreover, never use any of the supplements listed below without first consulting a medical doctor – to ensure that they are safe for you to take (based on your current medical status and medication regimen).

Affiliate disclosure: All of the products listed below contain affiliate links such that I earn a small commission if you purchase through my link.  That said, the price for each of the items is still the same (regardless of whether you buy through my link).  If you found this article helpful and want to support the website – I’d appreciate a purchase through my links.  (These are supplements I’d personally try if dealing with omeprazole withdrawal).

  • Zinc carnosine: Zinc carnosine is a supplement that is thought to significantly improve gut health and function. Some individuals find that taking 75 mg to 150 mg per day improves symptoms of rebound acid hypersecretion and counteracts excessive gastric acid production.
  • Glutamine powder: Glutamine is a supplement that has been shown to help restore intestinal tight gap junctions. Loss of tight gap junction integrity is frequently observed in “leaky gut syndrome” and among persons with dysbiosis.  To improve gut health while stopping omeprazole, glutamine should be considered. (Some claim that taking 3 to 5 grams of glutamine twice per day works well).
  • Deglycyrrhizinated licorice (DGL): DGL is a form of licorice that is allegedly very helpful in counteracting excessive acid secretion while discontinuing omeprazole. Ingesting 2 to 3 DGL tablets about 30 minutes before each meal has been suggested to counteract upset stomach and gut irregularities among persons with excessive stomach acid.
  • Digestive enzymes: Because your digestion may be impaired while withdrawing from omeprazole, it may be helpful to use digestive enzymes. Administering 2 to 3 capsules of digestive enzymes with each meal may help reduce indigestion and stomach pain associated with omeprazole discontinuation.
  • Ginger root: Ginger is another supplement that may help: alleviate gastrointestinal irritation, prevent acid reflux, and counteract inflammation – while withdrawing from omeprazole. If you haven’t yet tried supplementing with ginger and are experiencing debilitating withdrawal symptoms – it may be worth a try.
  • Probiotics: To ensure that your gut health remains optimized after stopping omeprazole, you may want to consider supplementing with a probiotic. Supplementing with a high-quality probiotic may help restore healthy gut bacteria, reverse preexisting gut abnormalities (e.g. intestinal permeability), and/or reduce peripheral inflammation.
  • Magnesium citrate: Preliminary evidence indicates that persons with gastrointestinal dysfunction commonly have magnesium deficiencies. This considered, some believe that supplementing with magnesium can help reduce the severity of acid reflux.  Because magnesium also reduces anxiety and muscle tension – it may be worth trying during omeprazole withdrawal.
  • Apple cider vinegar: Apple cider vinegar diluted in water has been suggested to improve symptoms of acid reflux by modifying stomach pH to neutralize stomach acid. Though there’s no guarantee that apple cider vinegar will help, many claim that it does.
  • Bone broth: High-quality bone broth is suggested to have numerous health benefits, one of which is enhancing gut health. Bone broth is understood to contain glutamine – an amino acid that appears to restore tight gap junctions within the gastrointestinal tract.
  • Multivitamin: It is understood that vitamin and mineral deficiencies might occur in long-term omeprazole users. If you’ve recently discontinued omeprazole, it may be smart to supplement with a multivitamin to ensure that you aren’t deficient in any major vitamins or minerals – as a deficiency might exacerbate withdrawal symptoms.
  • Sugar-free gum: Chewing sugar-free gum is another intervention that may help counteract omeprazole discontinuation symptoms. Some research suggests that chewing sugar free gum for 30 minutes after a meal can significantly decrease postprandial acidic gastroesophageal reflux.
  • Electrolytes: It’s possible that electrolyte levels may become imbalanced after stopping omeprazole – due to fluctuations in stomach acid. Because electrolyte deficiencies might cause and/or exacerbate certain withdrawal symptoms, you may want to consider using a high-quality electrolyte supplement.
  • Krill oil: Krill oil is a supplement that contains highly-bioavailable omega-3 fatty acids (DHA and EPA). The omega-3 fatty acids within krill oil are capable of reducing inflammation and counteracting oxidative stress.  Because inflammation and oxidative stress might increase during omeprazole withdrawal, it might be helpful to supplement with krill oil.
  • Curcumin: This is a supplement that is understood to decrease inflammation throughout the body. Because inflammation might increase after discontinuing omeprazole (due to changes in acid production and gut bacteria), curcumin supplementation is worth considering.  Furthermore, some claim that curcumin might even help reduce symptoms of gastroesophageal conditions.
  • Cayenne pepper extract: Though Cayenne pepper extract might exacerbate acid reflux for some individuals, others have reported that it completely counteracts their acid reflux symptoms. If you’re struggling with severe acid reflux after quitting omeprazole, you may want to consider trying Cayenne pepper supplementation.

Have you experienced Omeprazole withdrawal symptoms?

If you’ve successfully discontinued omeprazole, feel free to leave a comment about whether you experienced withdrawal symptoms.  If you experienced withdrawal symptoms after stopping omeprazole, mention: (1) when the withdrawal symptoms started (after discontinuing omeprazole); (2) the specific withdrawal symptoms that you experienced; (3) the severities of your symptoms; (4) how long your symptoms lasted; and (5) any tactics you used to reduce the severities of your symptoms.

Also provide additional details about your omeprazole treatment such as: how long you used omeprazole before discontinuing; the dosage that you used; whether you tapered off vs. quit cold turkey; and whether you used substances (e.g. acid reducing agents) in withdrawal.  Furthermore, be sure to mention the medical condition for which omeprazole was originally prescribed – and share why you decided to stop taking omeprazole.

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Omeprazole is used to treat problems affecting your stomach and gut, such as indigestion, reflux and ulcers. Find out how to take it safely and possible side effects. Omeprazole is also called Losec.

The colour of omeprazole capsules will be changing 
From 1 August 2021, the colour and packaging for omeprazole capsules will be changing. They are still made by the same company (Actavis) and the formulation remains the same.
  • Omeprazole 10 mg and 20 mg – the capsules and bottles for are changing.
  • Omeprazole 40 mg – the capsules remain the same, but the bottles will have a new look. 
Read more about omeprazole changes.

What is omeprazole?

Omeprazole reduces the amount of acid produced in your stomach. It belongs to a group of medicines known as proton pump inhibitors (PPIs). They are used to treat conditions associated with high stomach acid affecting your stomach and gut, such as indigestion, reflux and ulcers.Omeprazole can prevent ulcers from forming or help the healing process where damage has already occurred.

Omeprazolecan be used to prevent ulcers caused by medicines such as non-steroidal anti-inflammatory drugs (NSAIDs). Examples of NSAIDs are diclofenac, ibuprofen, naproxen.

Omeprazolecan also be given together with antibiotics to get rid of Helicobacter pylori, a bacteria found in your stomach that can cause ulcers. 

In New Zealand omeprazole is available as capsules and can be given as an injection in hospital.  


  • The usual dose of omeprazole is 20 mg a day.
  • For some people, 10 mg a day is enough, while others may need a higher dose of 40 mg a day.
  • It is best to take the lowest effective dose for the shortest possible time.
  • Your doctor will advise you how long to takeomeprazolefor (usually for 4 to 8 weeks). Some people may need to take it for longer.
  • The pharmacy label on your medicine will tell you how much omeprazole to take, how often to take it and any special instructions. 

How to take omeprazole

  • Timing: Take omeprazole at the same time each day, usually in the morning. Omeprazole is usually taken once a day, but some people may need to take it twice a day. Your doctor will tell you how often to take it. Omeprazole can be taken before or after food, although taking it before food is best.
  • Swallow the capsule whole with a glass of water. Do not crush or chew – the medicine doesn't work properly if the capsule is crushed or chewed. If you have difficulty swallowing the capsule, you can open it and sprinkle the pellets over some fruit juice or yoghurt and swallow the pellets without chewing.
  • Missed dose: If you forget to take your dose, take it as soon as you remember. But, if it is nearly time for your next dose, just take the next dose at the right time. Do not take double the dose.

Avoid long-term use of omeprazole

If you don’t need them, PPIs like omeprazole should not be taken long term, because of the possible side effects. There may be a small increased risk of bone fractures, chest infections, kidney problems and nutrient deficiencies such as low magnesium and vitamin B12.

If you’ve been taking omeprazole for reflux for longer than 4 to 8 weeks, and your symptoms seem to be well managed, it’s a good idea to talk to your healthcare provider about reviewing your medicine. They may recommend stepping down your treatment. This could include:

  • reducing your daily dose of omeprazole
  • taking omeprazole only when you experience the symptoms of heartburn and reflux (also known as on-demand therapy)
  • stopping treatment completely, as your symptoms may not return. It may be best to reduce the dose over a few weeks before stopping.

Read more about PPIs for heartburn and reflux Choosing Wisely, NZ 

Precautions before starting omeprazole

  • Are you pregnant, planning a pregnancy or breastfeeding?
  • Do you have problems with your liver?
  • Are taking any other medicines? This includes any medicines you are taking that you can buy without a prescription, as well as herbal and complementary medicines.

If so, it’s important that you tell your doctor or pharmacist before you start omeprazole. Sometimes a medicine isn’t suitable for a person with certain conditions, or it can only be used with extra care.

Side effects

Like all medicines omeprazole can cause side effects, although not everyone gets them. Often side effects improve as your body adjusts to the new medicine.

Rebound acid secretion

When omeprazole is stopped, a common side effect is rebound acid secretion, where the acid secretion in your stomach increases significantly. This should return to normal within 2 weeks. Because the symptoms of rebound acid secretion are the same as for reflux (such as indigestion, discomfort and pain in your upper stomach and chest, feeling sick and an acid taste in your mouth), it can form an ongoing loop where stopping omeprazole treatment creates the need to start it again.

Rather than restart omeprazole, your doctor may advise you to use medicines that contain both an antacid and an anti-foaming agent, such as Acidex oral liquid or Gaviscon Double Strength tablets. Alternatively, ranitidine tablets could be used. These can be effective for treating rebound acid secretion. You can use these medicines to relieve the symptoms when they occur.

Talk to your doctor or pharmacist about how to manage rebound acid secretion.

Other side effects

Side effectsWhat should I do?
  • Stomach upset, feeling sick
  • Feeling bloated, gas in your abdomen (tummy)
  • Loose stool (mild diarrhoea)
  • Constipation
  • These are quite common when you first start taking omeprazole.
  • Tell your doctor if troublesome.
  • Signs of low magnesium, such as muscle cramps, weakness, tiredness, feeling irritable and changes in your heartbeat
  • Increase your intake of magnesium-rich foods such as wholegrain cereals, green leafy vegetables (spinach, parsley, cabbage), peas, lean meats, nuts, seeds and bananas.
  • Tell your doctor if troublesome – you may need a magnesium supplement.
  • Severe diarrhoea (loose, watery, frequent stools)  
  • Omeprazole can increase the chance of getting severe diarrhoea (which may be caused by bacteria called clostridium difficle).
  • Stop omeprazole and tell your doctor immediately.
  • Signs of an allergic reaction such as rash, fever, painful joints
  • Tell your doctor immediately or phone Healthline 0800 611 116. 
  • Worsening stomach problems, such as really bad stomach pain, blood in your stool or black stools, vomiting blood or dark-coloured vomit
  • Tell your doctor immediately or phone Healthline 0800 611 116.


Omeprazole may interact with a few medicines and herbal supplements, so check with your doctor or pharmacist before starting omeprazole and before starting any new medicines.

Learn more

The following links have more information on omeprazole:

Omeprazole (Māori) NeZ Formulary Patient Information
Losec Medsafe Consumer Information Sheets, NZ


  1. Stopping proton pump inhibitors in older people BPAC, NZ 2019
  2. Proton pump inhibitors: When is enough, enough? BPAC, NZ, 2014
  3. Proton pump inhibitors and the risk of acute kidney injury. BPAC, NZ, 2016
  4. Omeprazole NZ Formulary
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Weaning Works: Why You Shouldn't Go Cold Turkey With Your PPI's

There’s been a lot of talk in the news recently about the dangerous long-term side effects of PPI’s, and it’s caused a bunch of chaos in the medical world. Proton pump inhibitors (particularly the larger brands like Prilosec, Nexium, and Prevacid) are among the most commonly prescribed drugs in the US, with more than 110 million prescriptions prescribed in 2010. Since then the numbers have only grown, with a startling percentage of the population currently dependent on these medications for the treatment of reflux and heartburn.

Unsurprisingly, the news that these medications have been linked with some pretty serious side effects from long-term use (we’re talking increased risk of kidney disease, vulnerability to nutritional deficiencies and infections, and even increased risk of heart disease and dementia), has caused a major panic among consumers.

There’s this incredible sense of urgency and pressure that patients are getting bombarded with, both by the media and by lawyers and even some doctors. It’s the “stop taking these right now or you’ll drop dead tomorrow” message, and it’s one you’ll see featured on billboards, the internet, or even on the local news. For patients who are currently taking these medications, it’s incredibly scary. They’re left terrified of taking their medications but unsure what the consequences of stopping them will be.

The fact of the matter is, going cold turkey with your PPI’s is one of the worst things you can do for yourself at this point.

If you’ve just recently started taking your PPI’s and you’re worried about the potential dangers, then it’s probably not too late to simply stop taking them. For patients who have been taking PPI’s regularly for years, though, things aren’t so simple.

One of the problems is that PPI’s were never intended to be used as a long-term treatment option for acid reflux. Your typical PPI should be taken for two to eight weeks, and when used as they’re intended these medications aren’t particularly dangerous. The problems begin to arise when patients become dependent on PPI’s for the long-term alleviation of symptoms.

PPI’s work by blocking the production of acid in your stomach, something which generally leads to the relief of reflux symptoms like heartburn. The problem is that stomach acid helps digest food, but also has a barrier function against various pathogens. When there’s less stomach acid, you’re left more vulnerable to nutritional deficiencies and infections. That’s not a huge issue if you’re taking the medication on an as-needed basis for a couple of weeks, but over the span of a few years that vulnerability drastically increases your risk of serious health problems.

These health risks are unsettling, and we commend our PPI patients that are determined to stop taking their medication and find an alternative solution to their reflux issues. What these long-term PPI users need to understand, though, is that it’s not safe to just go cold turkey with your PPI’s.

We’re seeing the stories about the patients who have tried going cold turkey, and it’s a painful and generally unsuccessful approach. Most patients have difficulty discontinuing their PPI’s because the amount of acid in their digestive system surges when they stop taking the drug, and they’re often left with symptoms like excruciating stomach pain and increased heartburn. The safest way to end your relationship with PPI’s is to slowly wean yourself off the medication.

It can be a long and complicated process, but if you’re committed to finding a less dangerous solution for your reflux issues then it’s the path you need to take. The journey doesn’t end once you’ve been successfully weaned off your PPI medication, though. Perhaps the most important part is determining what you’ll use in place of medication to keep your reflux and heartburn at bay, and that’s where we’re here to help. There are tons of treatment options available, and ones like anti-reflux surgery pose little to no health risks and offer a permanent solution to your reflux and GERD. Weaning off your PPI’s is important, but so is deciding what to do after that.

PPI medications are difficult to quit, which is why it’s so important to not take this journey alone. Talk to your reflux doctor if you want to discontinue your PPI’s, we’ll draw out a plan to help you safely wean yourself off the medication and work together to determine what treatment option will best alleviate your reflux symptoms without posing health risks. 


I Feel Terrible Coming Off Omeprazole, But Not Anymore

Have you been taking omeprazole for quite some time now? Then you know that after taking omeprazole for a while, it might be difficult to come off because of some side effects. Today, we’ll be talking about your problem ‘why I feel terrible coming off omeprazole.’

Before we get to the side effects of omeprazole, let’s talk a bit about the drug itself to understand better what happens.

Table of Content

Long Term Use of Omeprazole and Its Effect 

Omeprazole is a drug that is used for gastroesophageal reflux disease and peptic ulcer diseases. These are chronic diseases and may require long-term treatment with the drug. So, it’s not uncommon for people to take omeprazole for weeks to months.

Due to treatment, the condition of the gastric mucosa will improve. It’ll be able to provide adequate protection. In that case, there is no reason to continue therapy with omeprazole. 

However, coming off omeprazole might not be so easy for some people.

Withdrawal Symptoms Of Omeprazole

Many who have taken the drug on a long-term basis have complained of several withdrawal syndromes. Some of the most common side effects of omeprazole due to discontinuation are:


Immediately after quitting omeprazole, you may have heartburn. This intense pain is much similar to the ones caused by GERD or peptic ulcer disease. The pain after discontinuing omeprazole may even be worse than before.


If you’ve been taking omeprazole for quite some time now, then quitting may cause dyspepsia. Dyspepsia is another term for indigestion where the food digesting capability of the stomach is greatly reduced.

Gas in the Stomach

You may feel bloated after discontinuing long-term proton pump inhibitor omeprazole. The acid in the stomach causes the formation of more gas which might make you feel bloated. In this way, omeprazole can cause weight gain. 

Intense Pain due to Acid Reflux

Acid reflux causes acid to travel up from the stomach. This causes extreme pain in the chest and may even extend up to the throat. The acid may even reach your mouth, in which case you’ll be able to taste the acid (which is very sour, by the way).

Nausea and Appetite Reduction

After discontinuing omeprazole, you might feel nausea and suppression of appetite. This can also reduce your body weight.

Neurological and Psychological Changes

Several mental changes have been noted with omeprazole withdrawal. Some of these have a physiological basis, where others are purely psychological. They include:

  • Anxiety
  • Depression
  • Dizziness
  • Feeling a sense of fatigue
  • Insomnia
  • Headache

Why I Feel Terrible Coming Off Omeprazole?

To better understand these adverse effects of long-term omeprazole administration, we must realize how normal acid secretion works.

Normal Acid Secretion

Normally, when you eat food, it travels through the esophagus to the stomach. At the stomach, the presence of food stimulates the production of gastrin. Gastrin is a local hormone that causes the secretion of acid.

Gastrin travels through the blood to where the acid-secreting cells are. This all happens inside the stomach. Gastrin then stimulates these acid-secreting cells to pump out protons through the proton pump.

A proton pump is a type of cellular pump present in certain cells of the stomach. The job of this pump is to secrete proton or hydrogen ions. This hydrogen ion gets into the lumen of the stomach. Then, it combines with chlorine to form hydrochloric acid.

The hydrochloric acid in the stomach has many functions. It helps break down the food substances that you take. It also kills many of the harmful organisms which are present in the daily food you take. It is also necessary for the absorption of many nutrients.

However, this acid is harmful to the cells inside the stomach as well. So, there is a layer of thick mucus overlying them. Because of this layer, the cells lining the inner layer of the stomach remain protected.

In diseases like peptic ulcer disease, gastroesophageal reflux disease, heartburn, etc. The acid produced is excessive. 

This damages the cells of the stomach and causes cell death and ulceration. This results in the stimulation of the pain sensors giving the intense ‘heartburn.’

What Role Does Omeprazole Play In Acid Secretion?

Omeprazole is a drug that reduces acid secretion. They accomplish this by inhibiting the proton pump. Omeprazole molecules bind irreversibly to the ‘sodium hydrogen ATPase,’ the scientific name of the proton pump. Thus, the proton pump can’t secrete acid anymore.

The reduction in acid secretion is what causes the relief of the symptoms of the disease. Also, this reduction gives time for the damaged cells of the stomach to heal. So, omeprazole helps in recovering the stomach cells. 

How Does Omeprazole Cause Withdrawal Symptoms?

That’s all well and good, but why do these withdrawal symptoms occur? The human body has something that’s called a negative feedback system. This is necessary to keep the constant condition in the internal parts of the body.

A negative feedback system means that the output of a procedure reduces the cause of the procedure. You can think of it like this: The temperature outside decreases. Then, you’ll feel like putting on more clothes to keep your body temperature constant.  If the temperature decreases even further, then you might even turn the heater on.

Your body’s acid-secreting system works similarly. If the acidity of the stomach increases, less gastrin is secreted. This inhibits acid production. Alternatively, if there’s less acid in the stomach, more gastrin is secreted to increase acid production.

Long-term omeprazole administration throws this stomach acid-gastrin system. Because the acid-secreting proton pumps are inactivated, normal gastrin levels can’t increase acid production as they used to normally.

This results in more and more production of gastrin. Long-term administration of omeprazole chronically elevates gastrin levels.

When you come off omeprazole, the proton pumps are activated once again. However, the gastrin levels are super high. So, these cause excessive acid production in the stomach by the newly activated proton pumps. This is known as rebound gastric hypersecretion.

This elevated level of acid is what causes most of the symptoms of omeprazole withdrawal. Since the acid increases, it damages the stomach cells causing heartburn, and you start asking why I feel terrible coming off omeprazole?

The acid levels may be so high that they may come up through the esophagus to the throat. This is called gastric acid reflux. Nausea and dyspepsia, which occur, are also due to elevated levels of acid.

It is still uncertain why the neurological symptoms occur. However, scientists hypothesize that long-term use of omeprazole also changes the levels of important chemical regulators. If you stop taking omeprazole suddenly, these regulators are altered rapidly. This also causes anxiety, insomnia, depression, etc.

How Long Do Omeprazole Withdrawal Symptoms Last?

If you’re wondering when these symptoms go away, we have good news for you. The symptoms subside within two to four weeks of stopping omeprazole. 

We’ve seen that the main reason for the withdrawal symptoms is increased gastrin levels. After activation of the proton pump, these levels go down as well gradually. So, when these chemicals return to normal, the symptoms go away as well. 

The levels of gastrin, as well as other chemical regulators, normalize within this period. So, the withdrawal symptoms of omeprazole administration go away within that period.

How To Come Off Omeprazole?

You should never discontinue a drug without your physician’s prior notice. If you feel like your stomach is doing better, then it’s best to visit your physician. They can decide whether you should stop the drug or not.

If you need to discontinue, below are some of the methods which can help:

Reducing the dose slowly

Instead of suddenly stopping the drug, you can try reducing the dose. This gradual decrease of the dose is called weaning off. So how can you wean off omeprazole? Let’s look at an example below: 

Let’s consider that you’re taking 20 mg omeprazole twice a day. So, to wean off, you’ll take 20 mg only once a day. This will continue for one to two weeks. After that time is over, you can take 20 mg every other day. This, too, will go on for around one or two weeks.

You can try reducing the dose as well. Thus, you can reduce the dose like this before completely stopping the drug and tapering the dose of omeprazole before it minimizes the withdrawal symptoms.

Dietary Changes

You have to change some of your dietary habits to reduce acid secretion.

You can decrease the amount of carbonated soda. These beverages contain carbonic acid. This acid increases the acidity of the stomach. So, by avoiding these, you can reduce the acidity of the stomach. 

Caffeine is a big culprit in this case—caffeinated products like tea, coffee, etc., cause increased acid production. So, limiting caffeinated products goes a long way.

Don’t lie down immediately after a meal. This can ensure proper digestion of food. 

Eat smaller quantities of food, but more often. By doing this, you ensure that your stomach doesn’t remain empty. So, the acid in the stomach can’t build up. Thus, the symptoms of rebound acid hypersecretion reduce significantly. 

Lifestyle Changes

While going off omeprazole, you have to make several lifestyle changes towards the healthy side. Otherwise, you will still ask why I feel terrible coming off omeprazole. So, let’s look at the changes you need to make. 

You have to give up smoking. Smoking increases acid production in the stomach. So, by avoiding this, the stomach remains protected from excess acid. 

Ensure to keep your head raised while sleeping. This will prevent the excess acid from backing up to your esophagus and throat. You can use an additional pillow if necessary.

Decrease alcohol consumption to a minimum. 

Drink plenty of water because water dilutes the stomach acid.

Wait for a while after your meal before exercising.

Treating the Withdrawal Symptoms

If you’re experiencing withdrawal symptoms, your doctor can help you treat those symptoms specifically. Several medications are available for these symptoms. 

 Probiotic Supplements

Probiotic supplements are another helpful way to reduce rebound acid hypersecretion. The beneficial bacteria present in these supplements accelerate the normal digestion process. They also restore gut biome balance. 

So, if you want to come off omeprazole, a probiotic supplement may help you get relief.


Withdrawal effects of omeprazole include rebound acid hypersecretion, heartburn, acid reflux, gas, anxiety, nausea, insomnia, etc.

How long does PPI withdrawal syndrome last?

PPI withdrawal symptoms last for around two to four weeks.

Can omeprazole cause nerve damage?

Omeprazole doesn’t cause any permanent nerve damage; however, some nerve inflammation is present. Symptoms include tingling sensation or numbness.

Can I stop taking omeprazole suddenly?

If you’ve been taking omeprazole for longer than two months, you shouldn’t stop suddenly. You can try tapering the dose little by little.


The bottom line, getting off omeprazole isn’t easy. If you suddenly start asking why I feel terrible coming off omeprazole, this article will be a great help. 

With the proper dosage reduction, lifestyle changes, and medications, it is possible to discontinue omeprazole without side effects. 


Side omeprazole effects withdrawal

Because today I licked her delicious pussy. and fucked her a little. Truth less than I wanted.

PPI: Side Effects \u0026 Warnings - Dr. Chris Smith

I ran out into the street. Turned around. And he went - where his eyes were looking. He walked slowly.

Now discussing:

They installed a brazier, took out an ax, started chopping wood - in general, a purely man's work. The girls lay down on the bedspreads to bask in the sun. And it turned out that at first Yulka, not wanting it (or maybe, on the contrary, wanting?), Became the center of attention of me, Arthur and.

Lyokha. We were minding our own business, but I saw that everyone occasionally looks askance at Julia.

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